Abstract
This study was conducted to investigate the protective effect of Zingiben Officinale against the H2O2 induced oxidative stress in local male rabbits 5 – 6 months old . Rabbits were divided into 4 groups 4 rabbits each . Zingiben officinale was used as capsules at a dose of 1000 mg / kg. B. wt . The rabbits were treated dialy for 28 days . Oxidative stress was determined through measuring the levels of glutathione GSH and malondialdehyde MDA in liver tissue and of ALT and AST enzymes levels . H2O2 treatment showed significant decrease in liver tissue MDA and a significant increase liver tissue GSH serum AST and ALT were significantly increase also the above changes indicate the ability of H2O2 (1 %) in the induction of oxidative stress in local male rabbits .The treatment with zingiben officinale showed the following results significant decrease in ALT and AST serum levels , also significant decrease in liver tissue MDA and significant increase in GSH level , significant decrease in liver fat % These results indicate the protective effect of ZingibenOfficinal against oxidative stress .
