Abstract
The effect of carrot (Ca) juice on induction of chromosomal aberrations in white mice bone marrow cells was studied under natural conditions and induction of cyclophosphamide (Cp). Results showed that administration of juice (0.1, 0.25, 0.5)ml orally for 6 days had no effect on induction of chromosomal aberrations(Chromosomal breaks, Chromatid breaks, Ring chromosome and Dicentric chromosome), except that the higher dose (0.5 ml) elevated the level of chromosomal aberrations slightly and it was beyond the statistical significancy (P< 0.01). While oral administration of Cp (50 mg/Kg of animal body weight) increased the aberrations 9 times in comparison to the negative control , the latter level of aberrations was lower to 7 times due to natural defense processes of the body. Using the juice and mutagens in different combinations, such as using juice after administration of the mutagen (Cp/Ca), or using the juice before administration of mutagen (Ca/Cp) or administration both of them together resulted in lowering the aberrations in general, but the treatment of (Ca/Cp) was the best especially when used for 6 days.
