This study was designed to demonstrate the effect of using different levels of naringin and hesperidin on some blood and biochemical indicators and antioxidant status in aged broiler roosters. To achieve this goal, the birds were randomly distributed into six treatments as follows: The first treatment without any feed additions (NC). The second supplemented with vitamin E (20 IU per kg of feed) (PC). The third and fifth treatments received an addition of (250 mg/kg of feed) of both hesperidin and naringin, denoted as HS1 and NA1 respectively. The fourth and sixth were treated with an addition of (500 mg/kg of feed) of hesperidin and naringin, labeled as HS2 and NA2 respectively. The study aimed to investigate blood characteristics, certain biochemical indicators. When compared to treatments HS1, HS2, NC, and PC, the NA2 treatment clearly outperformed them in MCH and MCV. In comparison to the other treatments, the PC treatment showed a significant increase in (Hb), (PCV), and (TRBC). HS2 and NA2 treatments reduced WBC compared to NC. The hesperidin and naringin treatment resulted in lower quantities of glucose, cholesterol, and Malondialdehyde. Additionally, HS2 and NA2 showed improvement in activity of the enzymes GOT and GPT , and glutathione concentrations. Conclusions derived from the study's findings imply that the addition of hesperidin and naringin enhanced the birds' immunological capacities. This improvement was followed by a possible decline in glucose and cholesterol levels, which may have resulted from an increase in liver functioning and antioxidant status.