To determining effect of Coenzyme Q10 (CoQ10)and wheat germ oil(WGO) on hematological , and blood biochemical treats in rabbits buck exposed to oxidative stress, 54 animal aged 4-5 month randomly distributed into six group. Nine animals / group. as following: the first was a productive ration + tap water, the 2nd group consumption normal diet + Water with 0.04%H2O2, G3 and G5: supplemented CoQ10 100 mg/kg fodder without and with H2O2, respectively. Moreover, the G4 and G6: supplied 3 gm. WGO /kg of feed without and with H2O2 in drinking water, respectively. The results showed: No significant difference (P≤0.05) among group in the (RBC), G3 recorded a significant increase in the PCV, corresponding to a significant decrease in the MCV. The sixth group recorded increasing in the hemoglobin concentration, which led to a significant increase in the MCHC. The second treatment recorded decrease total protein, and globulin,. Regarding the lipid profile, there was a significant increase in the level of triglycerides and cholesterol with H2O2. There was a significant decrease in ALT and AST levels for the third and fourth treatments compared with the rest of the oxidative stress treatments. With a significant decrease in glucose concentration, creatinine, urea and cortisol levels.